Activation of glial cells in the spinal cord of a model of lumbar radiculopathy |
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Authors: | Shigeo Takahata Tsuneo Takebayashi Yoshinori Terasima Katsumasa Tanimoto Takuro Wada Hitoshi Sohma Yasuo Kokai Toshihiko Yamashita |
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Institution: | (1) Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan;(2) Department of Biomedical Engineering, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan; |
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Abstract: | Purpose Glial cells in the spinal cord of a lumbar radiculopathy model were investigated using immunohistochemical methods. Neuropathic
pain is a consequence of neural plasticity. In models of neuropathic pain models, roles for glial cells in the development
of pain behaviors have been reported. Accumulating evidence suggests that activation of p38 mitogen-activated protein kinase
(p38) in glial cells contributes to the pathogenesis of neuropathic pain. We examined whether activation of glial cells is
involved in the development of neuropathic pain-like behavior observed in a model of lumbar radicular pain that we developed.
However, the pathogenesis of lumbar radiculopathy and in particular the effect of spinal glial activation on pain transmission
in the dorsal horn of the spinal cord are still not fully known. |
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