Insulin resistance is not associated with myocardial steatosis in women |
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| Authors: | M. Krššák Y. Winhofer C. Göbl M. Bischof G. Reiter A. Kautzky-Willer A. Luger M. Krebs C. Anderwald |
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| Affiliation: | 1.Division of Endocrinology and Metabolism, Department of Internal Medicine III,Medical University of Vienna,Wien,Austria;2.Centre of Excellence, High-Field MR, Department of Radiology,Medical University Vienna,Vienna,Austria;3.Centre for Medical Physics and Biomedical Engineering,Medical University Vienna,Vienna,Austria;4.Siemens Healthcare,Vienna,Austria |
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| Abstract: | Aims/hypothesis Insulin resistance, an independent risk-factor for cardiovascular disease, precedes type 2 diabetes and is associated with ectopic lipid accumulation in skeletal muscle and liver. Recent evidence indicates that cardiac steatosis plays a central role in the development of diabetic cardiomyopathy. However, it is not known whether insulin resistance as such in the absence of type 2 diabetes is associated with heart steatosis and/or impaired function. We therefore assessed myocardial steatosis and myocardial function in a sample of women with normal insulin sensitivity, insulin resistance, impaired glucose tolerance (IGT) and type 2 diabetes. |
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