新疆老年维吾尔族2型糖尿病患者四肢动脉硬化与轻度认知功能障碍的相关性分析

目的 探讨新疆老年维吾尔族2型糖尿病患者四肢动脉硬化与轻度认知功能障的相关性。方法 选择性别和年龄配比的80例维吾尔族2型糖尿病老年患者及40例健康维吾尔族老年受试者，评估两组被试血压、血脂、血糖和动脉硬化指数及与蒙特利尔认知量表（MoCA）的相关性。结果 （1）糖尿病非轻度认知损害组或糖尿病MCI患者的收缩压（SBP）、舒张压（DBP）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、空腹血糖（FBG）、餐后2h血糖（2hPBG）和糖化血红蛋白（HbA1c）均较正常对照组显著升高（P<0.01），HDL较正常对照组显著降低（P<0.01），糖尿病MCI组患者的SBP和DBP较糖尿病非MCI患者显著升高（P<0.01）；（2）糖尿病非MCI组患者MoCA评分较正常对照组显著降低（P<0.01），而臂踝脉搏波传导速度（BaPWV）较对照组显著升高（P<0.01），糖尿病MCI组患者MoCA评分较糖尿病非MCI组显著降低（P<0.01），而BaPWV较糖尿病非MCI组显著升高（P<0.01）；（3）多因素Logistic回归分析显示SBP、DBP和BaPWV与MoCA评分密切相关（P<0.05或P<0.01）；（4）糖尿病患者MoCA评分与BaPWV呈负相关（r=-0.347，P=0.002）。结论 老年维吾尔族2型糖尿病患者四肢动脉硬化程度与认知功能障碍明显相关，随四肢动脉硬化程度加深而认知功能损害加重。

Analysis of Correlation between Limb Arteriosclerosis and Mild Cognitive Dysfunction in Elderly Uygur Patients with Type 2 Diabetes Mellitus in Xinjiang

Objective To investigate the correlation between limb arteriosclerosis and mild cognitive dysfunction in elderly Uygur patients with type 2 diabetes mellitus in Xinjiang. Methods Eighty elderly Uygur patients with T2DM and 40 healthy elderly Uygur subjects with comparable gender and age distribution were selected for evaluation of the correlation of blood pressure, blood lipids, blood glucose with the atherogenic index and with the Montreal Cognitive Assessment (MoCA). Results As compared to the control group, there were significant increases in systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG) and HbA1c(P<0.01), and significant decrease in high density lipoprotein (HDL) (P<0.01)in diabetic patients both with and without mild cognitive impairment (MCI). There were significant increases in SBP and DBP in patients with diabetic MCI than in diabetic patients without MCI(P<0.01). As compared to the control group, there were significant decrease in MoCA score(P<0.01)and significant increase in brachial ankle pulse wave velocity(BaPWV) (P<0.01)in diabetic patients without MCI; as compared to diabetic patients without MCI, there were significant decrease in MoCA score(P<0.01) and significant increase in BaPWV(P<0.01) in diabetic patients with MCI. In multivariate Logistic regression analysis, SBP, DBP and BaPWV were shown to be closely correlated with MoCA score(P<0.05 or P<0.01). MoCA score and BaPWV showed negative correlation in diabetic patients(r=-0.347,P=0.002). Conclusion The extent of limb arteriosclerosis showed significant correlation with cognitive dysfunction in elderly Uygur patients with T2DM, with the cognitive impairment aggravating with the intensification of limb arteriosclerosis.