血管内皮生长因子及C反应蛋白与高血压颈动脉粥样硬化的关系

目的:研究血管内皮生长因子(Vascular endothelial growth factor,VEGF)及C反应蛋白(C-reactive protein,CRP)与原发性高血压患者颈动脉粥样硬化的程度之间的关系。方法:将60例原发性高血压患者按颈动脉粥样硬化的程度分为颈动脉的内膜中层厚度(Intima media thickness,IMT)正常组,IMT增厚组和斑块形成组,分别测定其VEGF和CRP的水平,分析两者与动脉粥样硬化程度的关系。结果:IMT增厚组的VEGF和CRP的水平显著高于IMT正常组(P<0.01),斑块形成组的VEGF和CRP的水平显著高于IMT增厚组(P<0.01)。结论:VEGF和CRP水平与原发性高血压患者颈动脉粥样硬化的程度相关,血VEGF和CRP水平可作为原发性高血压患者病情判断的观察指标。

Relationship among vascular endothelial growth factor,C-reactive protein and carotid artery atherosclerosis in patients with essential hypertension

Objective: To study the relationship among vascular endothelial growth factor(VEGF),c-reactive protein(CRP) and the degree of carotid artery atherosclerosis in patients with essential hypetension.Methods:A total of 60 patients with essential hypertension were divided into intima media thickness(IMT) normal group,IMT incrasssation group and plaque development group.The level of VEGF and CRP were measured and the relationship among VEGF,CRP and the degree of carotid artery atherosclerosis in patients with essential hypertension were observed.Results:The level of VEGF and CRP in IMT incrasssation group were significantly higher than these in normal IMT group(P<0.01),and the level of VEGF and CRP in plaque development group were significantly higher than these in incrasssation group(P<0.01).Conclusions:Concentrations of VEGF and CRP are positively ralated to the degree of carotid artery atherosclerosis indicating they can be used as indexes to assess the disease status and the prognosis of essential hypetension.