米非司酮对子宫内膜异位症患者卵巢功能及血清CA125、HE4、CA199、炎性因子的影响

目的:观察米非司酮对子宫内膜异位症患者卵巢功能及血清CA125、HE4、CA199、炎性因子的影响。方法:选取2009年9月～2012年3月于本院就诊的58例子宫内膜异位症患者为研究对象,将其随机分为对照组(丹那唑组)和观察组(米非司酮组)每组各29例,后将两组治疗前和治疗后1个月、3个月卵巢功能相关指标、血清CA125、HE4、CA199及IL-4、TNF-α、TNF-β、hs-CRP、IL-8水平进行检测和比较。结果:观察组治疗后1个月、3个月卵巢功能相关指标改善程度均优于对照组,血清CA125、HE4、CA199及IL-4、TNF-α、TNF-β、hs-CRP、IL-8水平均低于对照组,且观察组治疗后3个月也均优于治疗后1个月,P均<0.05,有显著性差异。结论:米非司酮可有效改善子宫内膜异位症患者的卵巢功能,对患者的血清CA125、HE4、CA199及炎性因子也有积极的影响。

Influence of mifepristone on ovarian function and levels of serum CA125,HE4 and CA199,inflammatory factors of patients with endometriosis

Objective: To observe the influence of mifepristone on ovarian function and levels of serum CA125,HE4 and CA199,inflammatory factors of patients with endometriosis.Methods:A total of 58 patients with endometriosis treated in our hospital from September 2009 to March 2012 were selected as research object,and they were randomly divided into control group(danazol group)and observation group(mifepristone group)with 29 cases in each group.then Related indexes of ovarian function,serum CA125,HE4 and IL-4,TNF-α,TNF-β,hs-CRP,IL-8 of two groups before and 1,3 months after the treatment were detected and compared.Results:One and three months after the treatment,the improvement of ovarian function of observation group were all better than those of control group,serum serum CA125,HE4,IL-4,TNF-α,TNF-β,hs-CRP and IL-8 levels were all lower than those of control group.And the above mentioned levels detected 3 months after treatment were signficant better than that 1 month after the treatment(P all <0.05).Conclusions:The mifepristone can effectively improve ovarian function of patients with endometriosis,and it has active effect on the serum CA125,HE4,CA199 and inflammatory factors.