CT灌注成像在脑胶质瘤分级中的价值及与微血管密度的相关性

目的:探讨CT灌注成像在脑胶质瘤诊断中的应用价值及与微血管密度的关系。方法:选择脑胶质瘤患者70例,所有患者均接受颅脑CT灌注扫描,测量各感兴趣区的脑血流量、相对脑血流量、脑血容量及相对脑血容量值。检测肿瘤组织内微血管密度(Microvessel density,MVD)及血管内皮生长因子(Vascular endothelial growth factor,VEGF)表达。结果:(1)高级别胶质瘤CBF、rCBF、CBV及rCBV均显著高于低级别胶质瘤(P<0.01)。(2)高级别胶质瘤VEGF阳性比例为90.00%(36/40),显著高于低级别胶质瘤,其MVD表达平均为(69.76±7.82)个/HP,显著多于低级别胶质瘤(P<0.01)。(3)胶质瘤CT灌注rCBV值与MVD及VEGF表达间均具有显著正相关性(r=0.571和r=0.621,P均<0.05)。结论:高级别胶质瘤与低级别胶质瘤CT灌注成像参数存在明显差异,且rCBV值与MVD及VEGF间具有显著正相关性。

Application of CT perfusion imaging in glioma grading and its relationship with microvessel density

Objective: To investigate the value of CT perfusion imaging in the diagnosis of glioma and its relationship with microvessel density.Methods: A total of 70 glioma patients underwent brain CT perfusion scan were selected.ROIs cerebral blood flow,relative cerebral blood flow,cerebral blood volume and relative cerebral blood volume values were measured.Microvessel density and vascular endothelial growth factor expression in tumor tissue was detected.Results: CBF,rCBF,CBV and rCBV of high-grade gliomas was significantly higher than that of low-grade gliomas,and the differences were statistically significant(P<0.01).VEGF positive ratio of high-grade gliomas was 90.00%(36/40),significantly higher than the low-grade gliomas,average MVD was(69.76 ± 7.82)/HP,significantly more than the low-grade gliomas(P<0.01).rCBV values of glioma CT perfusion had significant positive correlation with MVD and VEGF expression(r=0.571,P<0.05;r=0.621,P<0.05).Conclusions: There are significant differences in gliomas CT perfusion imaging parameters between high-grade gliomas and low-grade,and there are significant positive correlation between rCBV and MVD&VEGF.