同步放化疗与单纯放疗治疗中晚期宫颈癌的临床疗效比较

目的:对比研究同步放化疗与单纯放疗治疗中晚期宫颈癌的临床疗效和毒副作用。方法:选择经病理确认为Ⅱb～Ⅳ期的宫颈癌患者46例,随机分为同步放化疗组23例和单纯放疗组23例。两组放疗方法及放疗剂量均相同,同步放化疗组在此基础上再采用静脉点滴的方法给予顺铂化疗,每4周进行一次,共进行3次,比较两组患者的近期、远期治疗效果和毒副作用。结果:同步放化疗组的近期有效率为95.23%(22/23),显著高于单纯放疗组的69.20%(16/23)(P<0.05);同步放化疗组的3年和5年生存率分别为86.96%、65.22%,显著高于单纯放疗组的60.87%、43.48%(P<0.05);同步放化疗组的毒副反应和放射性损伤等不良反应显著高于单纯放疗组(P<0.05),但经治疗后均能耐受。结论:同步放化疗法比单纯放疗对治疗中晚期宫颈癌具有较好的临床疗效,虽然其毒副反应较单纯放疗较高,但经治疗后均能耐受,不影响治疗。

Clinical efficacy of chemo radiotherapy and single radiotherapy treatment on advanced cervical cancer

Objective: To compare efficacy of chemo radiotherapy and single radiotherapy treatment on advanced cervical cancer and its side effects.Methods: A total of 46 cervical cancer cases at II b-IV stage confirmed by pathological analysis were selected and randomly divided into chemo radiotherapy group and radiotherapy group by half.The method and dosage of radiotherapy were the same in two groups.And patients in chemo radiotherapy group also had cisplatin combination chemotherapy for 3 times.every four weeks.Short-term,long-term treatment effects and side effects were observed and compared.Results:The short-term efficacy of chemo radiotherapy group was 95.23%(22/23),significantly higher than 69.20%(16/23) of the radiotherapy alone group(P<0.05);3 and 5-year survival rates of chemo radiotherapy group were 86.96% and 65.22%,significant higher than that of the radiotherapy alone group(60.87% and 43.48%)(P<0.05);toxicity and radiation adverse reactions of of the radiotherapy alone group was significantly higher than the radiotherapy alone group(P<0.05),but after treatment they were tolerable.Conclusions: Synchronous radiochemical therapy have better clinical efficacy than that with radiotherapy alone in treatment of advanced cervical cancer,although with higher toxicity and side effect.But after treatment it can be tolerated,and does not affect the efficacy.