老年非小细胞肺癌应用奈达铂加替吉奥联合三维适形放疗治疗的临床分析

目的:探讨奈达铂加替吉奥联合三维适形放疗治疗老年局部晚期非小细胞肺癌的临床疗效和安全性。方法:选取2010年1月～2011年1月于本院进行治疗的50例老年局部晚期非小细胞肺癌患者为研究对象,将其随机分为对照组(单纯三维适形放疗组)和观察组(奈达铂加替吉奥联合三维适形放疗组)每组各25例,后将两组患者的治疗总有效率、临床获益率、无疾病进展生存时间、1年生存率、不良反应发生率进行比较。结果:观察组的治疗总有效率及临床获益率分别为88.00%和96.00%,均明显高于对照组的56.00%和84.00%;而无疾病进展生存时间为(17.5±1.8)个月,高于对照组的(11.9±1.3)个月;1年生存率为72.00%,高于对照组的48.00%(P<0.05),有显著性差异。不良反应方面,观察组血液毒性高于对照组(P<0.05),有显著性差异;而两组放射性食管炎和放射性肺炎发生率无显著性差异(P>0.05)。结论:奈达铂加替吉奥联合三维适形放疗治疗老年局部晚期非小细胞肺癌的临床疗效可,且不良反应可耐受。

Clinical effects of Nedaplatin,Tegafur Gimeracil Oteracil Potassium capsule combined with three-dimensional conformal radiotherapy in elderly patients with locally advanced non-small cell lung cancer

Objective: To investigate the clinical effects and safety of Nedaplati,Tegafur Gimeracil Oteracil Potassium capsule combined with three-dimensional conformal radiotherapy in elderly patients with locally advanced non-small cell lung cancer.Methods: A total of 50 elderly patients with locally advanced non-small cell lung cancer that were treated in our hospital from January 2010 to January 2011 were selected and randomly divided into control group(only three-dimensional conformal radiotherapy group)and observation group(Nedaplatin,Tegafur Gimeracil Oteracil Potassium Capsule combined with three-dimensional conformal radiotherapy group)with 25 cases in each group,then the total effective rate,clinical benefit rate,progression-free survival,one-year survival rate and adverse reactions of two groups were compared.Results:The total effective rate and clinical benefit rate of observation group were 88.00% and 96.00%,and they were significant higher than 56.00% and 84.00% of observation group,progression-free survival time of the observation group was(17.5±1.8)months,significant longer than(11.9±1.3)months of the control group,one-year survival rate was 72.00%,and it was higher than 48.00% of control group(P<0.05).Hematological toxicity of the observation group was higher than that of control group(P<0.05).However,the rates of radioactive esophagitis and radiation pneumonitis of two groups was not significantly different(P>0.05).Conclusion:The clinical effects and safety of Nedaplatin,Tegafur Gimeracil Oteracil Potassium Capsule combined with three-dimensional conformal radiotherapy in the treatment of elderly patients with locally advanced non-small cell lung cancer is better,and the adverse reactions is tolerable.