WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea |
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| Authors: | M Nishikawa Y Tsurumi H Murai K Yoshida M Okamoto S Takase H Tanaka H Hirota M Hashimoto M Kohsaka |
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| Affiliation: | Exploratory Research Laboratoires, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan. |
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| Abstract: | WF-2421 is a novel aldose reductase inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be alpha-formamido-5'-(2-formamido-1-hydroxyethyl)- beta,2',6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence. The IC50 value of WF-2421 was 3 x 10(-8) M against partially purified aldose reductase of rabbit lens. |
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