中老年慢性阻塞性肺疾病急性加重期并发感染患者血清PCT及CRP的临床价值研究

目的:探讨中老年慢性阻塞性肺疾病急性加重期并发感染患者血清PCT及CRP的临床价值.方法:选择2014年12月至2016年4月符合纳入标准的中老年慢性阻塞性肺疾病患者127例,按照病情分为COPD缓解组(缓解组)以及COPD急性加重组(加重组),其中COPD急性加重组按照患者有无感染的情况再分为COPD急性加重并发感染(感染组)以及COPD急性加重未并发感染(无感染组),感染组再根据患者的肺功能进行分级.比较各分组以及分级之间的血清PCT以及CRP的水平以及变化.结果:COPD急性加重期血清PCT及CRP的水平均较COPD稳定期显著升高(P<0.05).COPD感染组的PCT及CRP水平较非感染组的PCT及CRP水平显著升高(P<0.05).急性加重期并发感染患者血清PCT及CRP水平在肺功能分级Ⅰ级、Ⅱ级、Ⅲ级患者中,呈逐渐上升趋势,且不同分级之间统计均有显著性差异(P<0.05).结论:COPD急性加重期合并感染患者的血清PCT及CRP水平显著升高,且随着肺功能的恶化,血清PCT及CRP水平升高更显著.

Clinical Value of Serum Procalcitonin and C-reactive Protein on Middle-aged and Elderly Chronic Obstructive Pulmonary with Acute Aggravating Concurrent Infection

Objective: To explore the clinical value of serum procalcitonin and C-reactive protein on middle-aged and elderly chronic obstructive pulmonary with acute aggravating concurrent infection. Methods:127 cases patients of chronic obstructive pulmonary disease met the inclusion criteria were chose in our hospital from December 2014 to April 2016, according to patient ' s condition, divided the COPD disease remission group(remission group) and COPD acute aggravating group (aggravating group). Then subdivided into COPD with acute aggravating infection group ( infection group) and COPD with acute aggravating infection-free group ( infection-free group) at the COPD acute aggravating group, infection group was graded according to the pa-tient's lung function. The different level of serum PCT and CRP on different grouping and classification were compared. Results: The levels of CRP and serum PCT at COPD acute aggravating group was significantly higher than those in stable phase ( P <0.05) . The level of PCT and CRP at COPD with acute aggravating in-fection group was significantly increased than infection-free group ( P <0.05) . The level of PCT and CRP at level Ⅰ,Ⅱ,Ⅲ lung grade function of COPD with acute aggravating infection group, showed a gradual up-ward trend, and the statistical difference was significant between different classification ( P <0.05) . Conclu-sion:The level of serum PCT and CRP on COPD with acute aggravating infection group are significantly in-creased, and increase more significantly with the deterioration of lung function.