胃癌脉管内癌栓中EGFRc-Met和Ki-67的相关性分析

目的:分析胃癌患者脉管内癌栓与EGFR、c-Met和Ki-67表达的关系及其对疾病预后影响.方法:检测EGFR、c-Met和Ki-67在88例胃癌组织,其中包括脉管内癌栓阳性者39例中的表达情况,分析脉管内癌栓阳性组与阴性组患者1年及3年生存率的差异.结果:脉管内癌栓阳性组中EG-FR、c-Met和Ki-67的强阳性表达率均高于脉管内癌栓阴性组,差异有统计学意义(P<0.05).脉管内癌栓阴性患者1年、3年生存率高于同期阳性组,差异有统计学意义(P<0.05).结论:EGFR、c-Met和Ki-67的表达与脉管内癌栓及患者预后密切相关,脉管内癌栓是胃癌患者预后不良的标志.

Correlation Analysis on EGFR c-Met and Ki-67 in Gastric Cancer with Intravascular Cancer Embolus

Objective:To analyze the expression of EGFR, c-Met and Ki-67 in gastric cancer with in-travascular cancer embolus and their influence on the prognosis. Methods: The expression of EGFR, c-Met and Ki-67 in 88 gastric cancer cases and 39 cases of intravascular cancer embolus were detected and the difference between 1-year and 3-year survival rate in cancer embolus positive and negative patients group were analyzed. Results:In gastric cancer tissue with intravascular cancer embolus, the strong positive expres-sion rates of EGFR, c-Met and Ki-67 were all higher than those in gastric cancer tissue without intravascular cancer embolus ( P<0.05) . The strong positive expression rates of EGFR, c-Met and Ki-67 in gastric cancer tissue without intravascular cancer embolus 1-year and 3-year survival rate were obviously higher than those of cancer embolus positive group ( P<0.05) . Conclusions: The expression and prognosis of EGFR, c-Met and Ki-67 are related to the gastric cancer with intravascular cancer embolus, and has rather poor prognostic significance in gastric cancer.