血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨

目的:探讨血清同型半胱氨酸(Hcy)与癫痫患者认知功能损害(MCI)的相关性.方法:将120例癫痫患者按照认知功能是否存在损害分为MCI组(51例)和非MCI组(69例),对两组患者Hcy、S-腺苷甲硫氨酸(SAM)、S-腺苷同型半胱氨酸(SAH)水平进行测定,并探讨Hcy水平与简易精神状态评价量表(MMSE)评分的相关性.结果:MCI组患者血清Hcy、SAH水平均明显高于非MCI组(P<0.05),MCI组患者血清SAM水平明显低于非MCI组(P<0.05),当血清Hcy水平<15.0μmoL/L时,患者MMSE评分与血清Hcy浓度无明显相关性(r=-0.19,P>0.05);当血清Hcy水平≥15.0μmoL/L时,患者MMSE评分与血清Hcy浓度呈负相关性(P<0.05).结论:血清Hcy与癫痫患者MCI有一定相关性,临床可据此进行辅助诊断.

The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy

Objective:To study the relationship between serum homocysteine ( Hcy) and cognitive im-pairment ( MCI) in patients with epilepsy. Methods:120 patients with epilepsy were divided into MCI group ( n = 51) and non MCI group according to the impairment of cognitive function ( n = 69) . The Hcy, S-aden-osine methionine ( SAM) , S-adenosine homocysteine ( SAH) levels of were determined, and the Hcy levels and simple mental state assessment scale ( MMSE) score were detected. Results:The serum level of Hcy andSAH of patients in MCI group were significantly higher than that in MCI group ( P < 0.05);SAM serum level in patients with MCI group was obviously lower than the MCI group ( P <0.05);while serum Hcy levels<15. 0 umoL/L, MMSE score and serum Hcy concentration in patients had no significant correlation ( r = 0.19, P> 0.19);When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had neg-ative correlation ( P < 0.05) . Conclusion:There are some correlations between serum Hcy and epilepsy pa-tients with MCI. Clinical diagnosis can be carried out accordingly it.