锦灯笼根和茎化学成分研究

目的 研究锦灯笼Physalis alkekengi var.franchetii根和茎的化学成分.方法 利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化,通过核磁共振谱、质谱等光谱数据鉴定化合物结构.结果 分离得到10个化合物,分别鉴定为β-谷甾醇(1)、胡萝卜苷(2)、木犀草素(3)、木犀草素- 7-O-β-D-葡萄糖苷(4)、异岩藻甾醇(5)、硬脂酸单甘油酯(6)、睡茄内酯A(7)、胡萝卜苷-6 '-O-硬脂酸酯(8)、齐墩果酸(9)、(Z)-9,10,11-三羟基-12-十八碳烯酸(10).结论 化合物6、8、10为首次从该属植物中分离得到,化合物S、7、9为首次从该植物中分离得到.

Chemical constituents in roots and stems of Physalis alkekengi var. franchetii

Objective To investigate the chemical constituents in the roots and stems of Physalis alkekengi var.franchetii.Methods The constituents were isolated by chromatography on silica,Sephadex LH-20 gel columns,medium pressure and semi-preparative HPLC and their structures were elucidated by chemical properties and spectroscopic analyses.Results Ten compounds were isolated and their structures were identified as β-sitosterol(1),daucosterol(2),luteolin(3),luteolin-7-O-β-D-glucoside(4),isofucosterol(5),glyceryl monostearate(6),withanolide A(7),daucosterol-6′-O-stearate(8),oleanolic acid(9),and(Z)-9,10,11-trihydroxy12-octadecenoic acid(10).Conclusion Compounds 6,8,and 10 are obtained from the plants in this genus for the first time.Compounds 5,7,and 9 are obtained from this plant for the first time.