乌拉尔甘草化学成分研究

目的 研究乌拉尔甘草Glycyrrhiza uralensis根的化学成分.方法 利用硅胶、聚酰胺、MCI、ODS、Sephadex LH-20柱色谱,RP-HPLC等技术对乌拉尔甘草70％乙醇提取物的醋酸乙酯萃取部位进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定.结果 分离得到14个化合物,分别鉴定为3,7-二甲基甘草黄酮醇(1)、甘草宁Ⅰ(2)、甘草香豆酮(3)、8-甲雷杜辛(4)、2'-hydroxyisolupalbigenin(5)、异驴食草酚(6)、去氢粗毛甘草素D(7)、glycyrin (8)、甘草酚(9)、刺甘草查耳酮(10)、甘草查耳酮B (11)、isoangustoneA(12)、甘草宁G(13)、5,7,4’-三羟基-6,8-二异戊烯基异黄酮(14).结论 化合物1为新化合物,化合物2～7首次从该植物中分离得到.

Chemical constituents from Glycyrrhiza uralensis

Objective To study the chemical constituents from the roots of Glycyrrhiza uralensis.Methods The chemical constituents in ethyl acetate fraction of 70% ethanol extract from the roots of G.uralensis were isolated and purified by chromatography on silica gel,polyamide,MCI,ODS,Sephadex LH-20 columns,and RP-HPLC.The structures were identified on the basis of physicochemical properties and spectral data analyses.Results Fourteen compounds were isolated and identified as 3,7-dimethyl licoflavonol(1),gancaonin I(2),licocoumarone(3),8-methylretusin(4),2′-hydroxyisolupalbigenin(5),isovestitol(6),dehydroglyasperin D(7),glycyrin(8),glycyrol(9),echinatin(10),licochalcone B(11),isoangustone A(12),gancaonin G(13),and 5,7,4′-trihydroxy-6,8-diisoprenylisoflavone(14).Conclusion Compound 1 is a new compound,and compounds 2—7 are isolated from this plant for the first time.