云贵腺药珍珠菜化学成分研究

目的对云贵腺药珍珠菜Lysimachia stenosepala var.flavescens的化学成分进行研究。方法运用硅胶柱、凝胶柱、中压柱、聚酰胺柱等色谱技术进行分离纯化,根据波谱数据进行结构鉴定。结果从云贵腺药珍珠菜乙醇提取物中分离得到12个化合物,分别鉴定为山柰酚(1)、槲皮素(2)、鼠李柠檬素(3)、山柰酚-3-O-β-D-葡萄糖苷(4)、槲皮素-3-O-β-D-葡萄糖苷(5)、山柰酚-3-O-α-L-鼠李糖苷-(1→2)-β-D-葡萄糖苷(6)、山柰酚-3-O-α-L-鼠李糖苷-(1→6)-β-D-葡萄糖苷(7)、槲皮素-3-O-β-D-木糖苷-(1→2)-O-β-D-葡萄糖苷(8)、山柰酚-3-O-(2-O-α-L-鼠李糖苷-6-O-β-D-木糖苷)-β-D-葡萄糖苷(9)、β-谷甾醇(10)、原报春花素A(11)、β-胡萝卜苷(12)。结论化合物1～12为首次从该植物中分离得到,其中化合物8、9为首次从珍珠菜属中分离得到。

Chemical constituents of Lysimachia stenosepala var. flavescens

Objective To investigate the chemical constituents in Lysimachia stenosepala var.flavescens.Methods Compounds were isolated by chromatography on silica gel,Sephadex LH-20,and polyamide columns and their structures were identified by spectral data.Results Twelve compounds were identified as kaempferol(1),quercetin(2),rhamnocitrin(3),kaempferol-3-O-β-D-glucopyranoside(4),quercetin-3-O-β-D-glucopyranoside(5),kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-Dglucopyranoside(6),kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(7),quercetin-3-O-β-D-xylopyranosyl-(1→2)O-β-D-glucopyranoside(8),kaempferol-3-O-(2-O-α-L-rhamnopyranosyl-6-O-β-D-xylopyranosyl)-β-D-glucopyranoside(9),β-sitosterol(10),protoprimulagenin A(11),and β-daucosterol(12).Conclusion Compounds 1—12 are isolated from this plant for the first time and compounds 8 and 9 are isolated from the plants in Lysimachia L.for the first time.