安徽省192例HIV阳性结核病患者的治疗转归分析

目的 了解安徽省AIDS高流行县（区）通过积极的干预措施，对HIV与Mtb双重感染患者结核病治愈率和病死率的影响。方法 收集分析安徽省AIDS高流行的7个县（区）2006年10月1日至2009年6月30日发现的199例Mtb与HIV双重感染患者抗结核疗程结束后的转归情况。结果 Mtb与HIV双重感染患者中进行抗病毒治疗者135例，抗结核治疗者192例，181例接受了全程督导，疗程结束后1年内结核病治愈48例，完成疗程113例，迁出4例，死于结核病4例，死于非结核病21例,治疗失败1例，丢失1例。Mtb与HIV双重感染患者的治疗成功率为83.9％（161/192），总病死率13.0％（25/192），其中因结核病死亡率2.1％（4/192）。结论 各级结核病防治机构与艾滋病防治机构合作，积极发现Mtb与HIV双重感染并进行及时的抗结核和抗病毒治疗，能有效提高Mtb与HIV双重感染患者的结核病治愈水平，降低病死率。

Analysis on the anti-tuberculosis treatment outcome of 192 Mtb/HIV co-infected patients in Anhui province

Objective To understand the impact of active interventions on improving TB cure rate and reducing the fatality rate among Mtb/HIV co-infected patients in HIV high epidemic areas in Anhui province.Methods Information of the anti-TB treatment outcome of 199 Mtb/HIV co-infected patients registered from October 1 2006 to June 30 2009 in 7 high HIV epidemic counties was collected and analyzed.Results Among the 199 Mtb/HIV co-infected patients,135 cases received antiretroviral therapy,192 cases received anti-TB treatment and 181 cases accepted full course supervision.Within 1 year after the completion of anti-TB treatment,of co-infected patients 48 cases recovered from TB,113 cases completed the treatment course,4 cases were transferred out,4 cases died of TB,21 cases died of non-TB diseases,1 case failed and 1 case was lost.The treatment success rate of Mtb/HIV co-infected patients was 83.9%(161/192),the total fatality rate was 13.0%(25/192)while the fatality rate of TB was 2.1%(4/192).Conclusion The active cooperation between TB institutes and AIDS institutes of different levels would improve the detection of Mtb/HIV co-infected patients and provide timely diagnosis and treatment of both di-seases which could effectively increase the TB cure rate and reduce the fatality rate among Mtb/HIV co-infected patients.