| 小粒径氟尿嘧啶羧甲基壳聚糖微球制备工艺初探 |
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| 引用本文： | 郑景峰,刘喆,蒋智清.小粒径氟尿嘧啶羧甲基壳聚糖微球制备工艺初探[J].海峡药学,2013,25(9):26-28. |
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| 作者姓名： | 郑景峰 刘喆 蒋智清 |
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| 作者单位： | 郑景峰 (福建省药品检验所,福州,350001)； 刘喆 (北京天坛生物制品股份有限公司,北京,100024)； 蒋智清 (福建医科大学药学院基础化学系,福州,350004)； |
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| 基金项目： | 福建医科大学青年教师科研基金资助项目(项目编号：FJGXQ04024) |
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| 摘 要： | 目的初步探讨氟尿嘧啶羧甲基壳聚糖（FU-CMCS）微球制备工艺及体外释药特性。方法以羧甲基壳聚糖（CMCS）为载体材料。采用乳化交联法制备氟尿嘧啶羧甲基壳聚糖（FU-CMCS）微球。考察投药方式、交联剂、超声乳化作用等因素对微球粒径、体外释药的影响。结果该方法制得FU-CMCS微球平均粒径1．6μm，球形圆整、流动性良好，人工肠液释药长迭15d。结论该制备工艺方法简单，制得FU—CMCS微球粒径小，分布窄，在体外具有缓释作用。
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| 关 键 词： | 氟尿嘧啶 羧甲基壳聚糖 微球 体外释放 |
Studies on the preparation technology of small particle size of carboxym- ethyl chitosan microspheres |
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| ZHENG Jing-feng,LIU Zhe,JIANG Zhi-qing.Studies on the preparation technology of small particle size of carboxym- ethyl chitosan microspheres[J].Strait Pharmaceutical Journal,2013,25(9):26-28. |
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| Authors: | ZHENG Jing-feng LIU Zhe JIANG Zhi-qing |
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| Institution: | (I. Fujian Institute for Drug control, Fuzhou 350001 ,China; 2. Beijing Tiantan Biology and pharmacy Engineer Co. ltd., Beijing 100024, China;3. Department of Basic Chemistry, College of Pharmacy, Fujian Medical University, Fuzhou 350004, China) |
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| Abstract: | OBJECTIVE To discusse the microsphere preparation technology of the FU-CMCS and the charac- teristics of external drug release. METHODS Based on the carrier material of CMCS, emulsion crosslinking was a- dopted to manufacture the FU-CMCS. The effeet of drug delivery way,crosslinking agent and the effect of ultrasonic emulsification on the microphere＇s paticle size distribution and in vitro drug release were studied. RESULTS The mierosphere＇s average particle size was 1.6 μm, with rounding ball and good liquidity, the time of the drug release of its artificial intestinal juice was long to 15 days. CONCLUSION This technology is simple with small, mierosphere＇ s particle size and narrow distribution, which owns sustained-release effect in virto. |
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| Keywords: | Fluorouracol Carboxymethyl chitosan Microspheres In vitro release |
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