血液透析患者颈动脉粥样硬化与血镁的关系研究

目的 探讨血液透析(HD)患者颈动脉粥样硬化(AS)与血镁(Mg)的关系.方法 检测107例HD患者一般临床指标,同时应用高频B超检测患者颈动脉内膜-中层厚度(IMT)及粥样硬化斑块,根据斑块有无分为阳性及阴性组,分析患者颈AS与血Mg的关系.结果 粥样硬化斑块阳性的HD患者在年龄、血磷(P)、总胆固醇(TCH)、低密度脂蛋白(LDL)、C-反应蛋白(CRP)、白蛋白(Alb)、Mg方面比较差异有统计学意义(ι=4.153,2.908,2.301,6.322,5.791,2.341,7.778,P＜0.01或P＜0.05).Logistic回归分析发现,AS的危险因素为:血Mg、CRP(P＜0.01).结论 HD患者AS的发生与微炎症、低镁血症有关.

Association between carotid atherosclerosis and serum magnesium in hemodialyzed patients

Objective To investigate the association between carotid atherosclerosis（AS） and ser- um magnesium （Mg） in hemodialyzed （HD） patients. Methods Clinical index was measured, and intima- media thickness （IMT） of extracranial common carotid artery and presence of atherosclerotic plaques were determined by high-resolution B-mode uhrasonography. The data were analyzed between plaque positive group and plaque negative group. Results The age, serum phosphate （P）, total cholesterol （TCH）, low density lipoprotein （LDL）, serum C-reactive protein （CRP）, serum albumin（Alb）, and serum Mg all had significant difference between two groups（ t =4. 153,2. 908,2. 301,6. 322,5. 791,2. 341,7. 778, P 〈0. 01 or P 〈 0. 05）. The risk factors of HD patients with AS were serum Mg and CRP（ P 〈 0. 01 ）. Conclusions The occurrence of AS was related to low Mg and high CRP in HD patients.