Gastric anti-ulcer activity of several alpha,beta-unsaturated carbonyl compounds in rats |
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| Authors: | Maria A O Donadel S Wendel G H Guzman J A Guerreiro E Giordano O S |
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| Affiliation: | Departamento de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina. alemaria@unsl.edu.ar |
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| Abstract: | The gastric cytoprotective activity of several molecules containing an alpha,beta-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the beta carbon of the Michael acceptors of the compounds assayed. |
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