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促进真皮替代物血管化进程的因素
引用本文:周显玉,杨军. 促进真皮替代物血管化进程的因素[J]. 组织工程与重建外科, 2012, 8(6): 344-348. DOI: 10.3969/j.issn.1673-0364.2012.06.013
作者姓名:周显玉  杨军
作者单位:上海交通大学医学院附属第九人民医院整复外科
基金项目:上海市科委科研计划项目(10411964200)
摘    要:对于严重大面积烧伤患者,自体皮肤组织移植常难以实施。尽管真皮替代物以其优良的理化特性,在烧伤重建外科领域发挥了重大作用,但与传统皮片移植相比,仍存在着血管延迟长入真皮层的缺陷。本文就真皮替代物的特性,以及移植后血管化进程的促进因素进行综述。

关 键 词:真皮替代物  血管生成  细胞因子  干细胞  基因介导载体  

Advance of Revascularization of Dermal Substitutes after Prefabrecation
ZHOU Xianyu,YANG Jun. Advance of Revascularization of Dermal Substitutes after Prefabrecation[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2012, 8(6): 344-348. DOI: 10.3969/j.issn.1673-0364.2012.06.013
Authors:ZHOU Xianyu  YANG Jun
Affiliation:Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China
Abstract:It is really difficult to launch the autologous skin grafting when facing severely burned patients with large skin defects. Regardless of the splendid physicochemical and biochemical characteristics of dermal substitute in burns and reconstructive surgery, a manifest drawback of current dermal substitutes technologies is the apparent delay in vascular ingrowth compared with conventional skin grafts. The characteristics and factors accelerating the revascularity of dermal substitutes after transplantation were reviewed.
Keywords:Dermal substitute  Revascularity  Cytokines  Stem cells  Gene-mediated carrier
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