| 基因工程HBsAg纯化技术的研究进展 |
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| 引用本文： | 潘太健,马瑞,曹春来,彭韪,孙万邦,肖拥军. 基因工程HBsAg纯化技术的研究进展[J]. 中国药业, 2012, 0(22): 21-23 |
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| 作者姓名： | 潘太健 马瑞 曹春来 彭韪 孙万邦 肖拥军 |
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| 作者单位： | 珠海联邦制药股份有限公司生物研究所;遵义医学院珠海校区·贵州省免疫学研究生教育创新基地 |
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| 摘 要： | 乙型肝炎病毒表面抗原（HBsAg）是乙肝疫苗（hepatitis B vaccine）的重要组成部分,注射乙肝疫苗是目前预防乙型肝炎感染最有效的方法。血源性乙肝疫苗因成本、来源和潜在其他病毒的感染已被淘汰,取而代之的是基因工程技术生产的第2代重组乙肝疫苗。主要介绍了国内外重组HBsAg在样品净化捕获、中度纯化和精纯3个阶段的主流纯化技术。
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| 关 键 词： | 基因工程 乙型肝炎病毒表面抗原 纯化技术 |
Research Progress in Purification Technology of Genetically Engineered HBsAg |
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| Pan Taijian,Ma Rui,Cao Chunlai,Peng Wei,Sun Wanbang,Xiao Yongjun. Research Progress in Purification Technology of Genetically Engineered HBsAg[J]. China Pharmaceuticals, 2012, 0(22): 21-23 |
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| Authors: | Pan Taijian Ma Rui Cao Chunlai Peng Wei Sun Wanbang Xiao Yongjun |
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| Affiliation: | 1,2(1.Research Institute of Biology,Zhuhai Union Pharmaceutical Co.,Ltd.,Zhuhai,Guangdong,China 519041;2.Zhuhai Campus,Zunyi Medical College,Zhuhai,Guangdong,China 519041) |
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| Abstract: | Hepatitis B surface antigen（HBsAg） is the important component of hepatitis B vaccine and injecting hepatitis B vaccine is the most effective way to prevent hepatitis B.As a result of high costs,limited sources and potential infection,the plasma-derived hepatitis B vaccine is replaced by the second generation of recombinant HBsAg produced by genetic engineering technology.This paper summarizes the mainstream purification technology during 3 stages of sample purification capture,intermediate purification and fine purification of recombinant HBsAg at home and abroad. |
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| Keywords: | genetic engineering hepatitis B surface antigen（HBsAg） purifica tion technology |
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