| 一氧化氮合酶和血管紧张素转换酶基因多态性与冠心病相关性研究进展 |
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| 引用本文： | 房超,曾慧,周宏灏,刘昭前. 一氧化氮合酶和血管紧张素转换酶基因多态性与冠心病相关性研究进展[J]. 中国临床药理学与治疗学, 2013, 18(2): 222-228 |
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| 作者姓名： | 房超 曾慧 周宏灏 刘昭前 |
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| 作者单位： | 1. 中南大学临床药理研究所,湖南省遗传药理学重点实验室,长沙410078,湖南
2. 长沙卫生职业学院,长沙410100,湖南 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金，湖南省自然科学创新群体基金 |
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| 摘 要： | 冠状动脉性心脏病（coronary heart dis-ease,CHD）是全球关注的公共卫生问题,是影响人类健康和寿命的关键疾病之一。一氧化氮合酶（eNOS）和血管紧张素转换酶（ACE）是体内对心血管系统具有重要作用的两种酶。基因组学研究发现eNOS和ACE基因多态性与CHD的发生具有相关性,本文就eNOS和ACE基因多态性与冠心病的易感性进行综述。
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| 关 键 词： | 冠心病 一氧化氮合酶 血管紧张素转换酶 基因多态性 |
Research progress on relationship between eNOS and ACE gene polymorphisms and coronary heart disease |
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| FANG Chao,ZENG Hui,ZHOU Hong-HaoI,LIU Zhao-Qian. Research progress on relationship between eNOS and ACE gene polymorphisms and coronary heart disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 222-228 |
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| Authors: | FANG Chao ZENG Hui ZHOU Hong-HaoI LIU Zhao-Qian |
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| Affiliation: | 1 Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Genetic Pharmacology, Changsha 410078, Hunan, China; 2 The Health Vocational College of Changsha , Changsha 410100, Hunan, China |
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| Abstract: | Coronary heart disease （CHD） is one of the most serious disease that affects hu- man health and life. It is also a public health problem concerned worldwide. The nitric oxide synthase （eNOS） and angiotensin-converting en- zyme （ACE） have an important influence on the cardiovascular system in vivo. The genomies study found that the eNOS and ACE gene poly- morphism correlate with the occurrence of CHD. This article covers the progress between eNOS and ACE gene polymorphism and coro- nary heart disease susceptibility. |
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| Keywords: | Coronary heart disease Endo- thelial nitric oxide synthase Angiotensin con- verting enzyme Gene polymorphism |
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