| 抗肿瘤纳米制剂药代动力学评价的研究进展 |
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| 引用本文： | 罗丹,张经纬,周芳,吴晓兰,王广基.抗肿瘤纳米制剂药代动力学评价的研究进展[J].中国临床药理学与治疗学,2013,18(2):205-211. |
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| 作者姓名： | 罗丹 张经纬 周芳 吴晓兰 王广基 |
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| 作者单位： | 中国药科大学药物代谢动力学重点实验室,南京210009,江苏 |
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| 基金项目： | 国家自然科学基金资助，江苏省自然科学基金，中央高校基本科研业务经费项目 |
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| 摘 要： | 抗肿瘤药物水溶性差、药代动力学行为不理想等特征在临床应用中严重影响疗效。抗肿瘤纳米制剂的开发可以实现药物増溶的目的,能够改善抗肿瘤药物的药代动力学行为,具有良好的应用前景。本文综述了抗肿瘤纳米制剂的研究现状,分别从整体和细胞水平介绍其药代动力学行为特征,探讨抗肿瘤纳米制剂发挥优势可能的作用机制。
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| 关 键 词： | 药物传递系统 多药耐药 纳米制剂 |
Research progress on the PK evaluation of anti-cancer nano-preparation |
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| LUO Dan,ZHANG Jing-wei,ZHOU Fang,WU Xiao-lan,WANG Guang-ji.Research progress on the PK evaluation of anti-cancer nano-preparation[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2013,18(2):205-211. |
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| Authors: | LUO Dan ZHANG Jing-wei ZHOU Fang WU Xiao-lan WANG Guang-ji |
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| Institution: | Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanj ing 210009, Jiangsu, China |
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| Abstract: | The poor water-solubility and pharmacokinetics of anticancer drugs will cause significant problems during clinical application. Developing nano-preparations is a reliable and safe way to improve the water solubility and pharmacokinetics of anticancer drugs, which possesses a promising prospect in both research and application in recent years. On the basis of recent studies, the pharmacokinetics of nano- preparation in vivo and in vitro and the mecha- nisms underlying the advantages of nano-prepa- rations are reviewed in this paper. |
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| Keywords: | Drug delivery system Multidrug resistance Nano-Preparation |
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