基础FSH/LH比值在控制性卵巢刺激中的意义

目的:探讨基础FSH/LH比值在控制性卵巢刺激(COS)中的意义。方法:将156个体外受精-胚胎移植(IVF-ET)周期的基础FSH/LH比值分为<1、1～2、>2三组,比较三组的年龄、体重指数、Gn起始剂量、Gn总量、Gn天数、总获卵数、临床妊娠率。结果:三组的年龄、体重指数、Gn用药天数及临床妊娠率差异无统计学意义,基础FSH/LH比值<2的Gn起始剂量和Gn总量明显低于比值>2组(P<0.05),而获卵总数高于比值>2组(P<0.05)。结论:FSH/LH比值可以预测卵巢反应性,在COS中计算Gn起始剂量具有临床指导意义。

Significance of basal FSH/LH ratio in controlled ovarian stimulation

Objective:To explore the significance of basal follicle-stimulating hormone(FSH)/luteinizing hormone(LH) ratio in controlled ovarian stimulation(COS).Methods:Basal FSH/LH ratios of 156 in vitro fertilization-embryo transfer(IVF-ET) cycles were divided into basal FSH/LH ratio <1 group,basal FSH/LH ratio 1-2 group,basal FSH/LH ratio >2 group;the ages,body mass indexes(BMI),initial doses,total doses,and application times of gonadotropin,the total numbers of retrieved oocytes,and clinical pregnancy rates in the three groups were compared.Results:There was no statistically significant difference in age,BMI,application time of gonadotropin,and clinical pregnancy rate among the three groups;the initial dose and total dose of gonadotropin in basal FSH/LH ratio <2 group were statistically significantly lower than those in basal FSH/LH ratio > 2 group(P<0.05),the total number of retrieved oocytes in basal FSH/LH ratio <2 group was statistically significantly higher than that in basal FSH/LH ratio > 2 group(P<0.05).Conclusion:FSH/LH ratio can predict ovarian response.Calculating the initial dose of gonadotropin has clinical guiding significance during COS.