| 维吾尔族妇女子宫颈癌CCNA1基因甲基化检测 |
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| 引用本文： | 刘引引,张金莉,李玉华,李星,康华丽,龙海晨,左强强,潘泽民. 维吾尔族妇女子宫颈癌CCNA1基因甲基化检测[J]. 中国妇幼保健, 2013, 28(11): 1791-1792 |
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| 作者姓名： | 刘引引 张金莉 李玉华 李星 康华丽 龙海晨 左强强 潘泽民 |
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| 作者单位： | 1. 石河子大学新疆地方与民族高发病教育部重点实验室,新疆石河子832002;石河子大学医学院生物化学教研室,新疆石河子832002
2. 喀什地区第一人民医院病理科 |
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| 基金项目： | 国家自然科学基金项目(项目编号：.30860302,30660193)促进与美大地区科研合作与高层次人才培养项目(项目编号：教外司美(2011),1056号)国际合作与交流专题项目(项目编号：2010DFB34100) |
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| 摘 要： | 目的:探讨CCNA1基因启动子区域甲基化与维吾尔族妇女子宫颈癌的相关性。方法:采用甲基化特异性PCR(MSP)方法,对40例子宫颈癌患者手术切除肿瘤组织及其40例正常子宫颈组织CCNA1基因启动子区域甲基化进行检测。结果:CCNA1基因在40例子宫颈癌中甲基化率为87.5%,正常子宫颈组织中甲基化率为2.5%,两者比较差异有统计学意义(P<0.01)。结论:CCNA1基因启动子甲基化与维吾尔族妇女子宫颈癌发生相关。
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| 关 键 词： | 子宫颈癌 CCNA1基因 甲基化 |
Detection of CCNA1 gene methylation in Uyghur women with cervical cancer |
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| Abstract: | Objective:To explore the correlation between CCNA1 gene promoter region methylation and cervical cancer in Uyghur women.Methods:DNA methylation-specific PCR(MSP) method was used to detect CCNA1 gene promoter region methylation in tumor tissue samples obtained by surgery from 40 patients with cervical cancer and normal cervical tissue samples from 40 healthy cases.Results:The rate of CCNA1 gene promoter methylation in 40 patients with cervical cancer was 87.5%,and the rate of CCNA1 gene promoter methylation in normal cervical tissue samples was 2.5%,there was statistically significant difference between the two groups(P<0.01).Conclusion:CCNA1 gene promoter region methylation is correlated with the occurrence of cervical cancer in Uyghur women. |
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| Keywords: | Cervical cancer CCNA1 gene Methylation |
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