妊娠合并糖代谢异常孕妇动态血糖图谱变化分析

目的:探讨妊娠糖尿病与糖尿病合并妊娠孕妇的动态血糖图谱变化特征,为临床治疗提供参考。方法:对妊娠糖尿病与糖尿病合并妊娠孕妇128例进行72h连续血糖图谱分析。结果:糖尿病合并妊娠组(65例)空腹血糖值、血糖波动系数、低血糖发生率高于妊娠糖尿病组(63例),妊娠糖尿病组血糖达峰时间长且低血糖发生少。结论:妊娠糖尿病患者与糖尿病合并妊娠患者在基线空腹血糖值及糖化血红蛋白值一致的情况下,动态血糖图谱仍存在差异,动态血糖图谱能够反映妊娠合并糖代谢异常孕妇的血糖波动全貌,为精细调节糖代谢和个体化用药提供参考。

Continuous glucose monitoring in women with gestational impaired glucose tolerance

Objective: To explore the fluctuating blood glucose in women with gestational diabetes mellitus (GDM) and those with pregestational diabetes mellitus (PGDM) by the continuous glucose monitoring system (CGMS) in order to provide the basis for clinical treatment. Methods: Sixty-three women with GDM and sixty-five ones with PGDM underwent the continuous glucose monitoring. Data derived from the CGMS for 72 hours were evaluated. Results: Fasting blood glucose (FBG) level and fluctuation coefficient in PGDM group were much higher than those of GDM group. There were less hypoglycemia and much more time was needed for peak blood glucose after meal in GDM group. Conclusion: There are still differences in blood glucose profiles of the CGMS for 72h between the two groups though the changes of the FBG level and the concentration of HbA1c are consistent. The fluctuating blood glucose level is recommended for fine regulating the glucose metabolism and personalized medication.