血清性激素、血脂水平与围绝经期症状的相关性

目的:研究女性血清性激素、血脂水平与围绝经期症状的相关性。方法:对215例女性进行一般情况、绝经期生存质量量表、绝经指数(KMI)等调查。从中筛选研究对象共90例,分为:①育龄对照组(20例);②围绝经期组(17例);③绝经早期组(21例);④绝经晚期组(22例);⑤激素补充治疗(HRT)组(10例)。分别测定血清雌二醇(E2)、卵泡刺激素(FSH)、雄激素(T)、总胆固醇(TC)及甘油三酯(TG)的水平,比较各组E2、FSH、T、TC及TG测定值、围绝经期症状及KMI评分,并分析其相关性。结果:①与健康育龄组比较,围绝经期组、绝经早期组、绝经晚期组E2、T水平明显下降,FSH水平明显升高,差异有统计学意义(P<0.05);②围绝经期组、绝经早期组及绝经晚期组女性KMI逐渐增加,明显高于健康育龄女性,差异有统计学意义(P<0.05)。E2水平与KMI负相关(r=-0.334,P=0.001),T水平与KMI负相关(r=-0.270,P=0.010),FSH水平与KMI正相关(r=0.504,P=0.000);③与健康育龄组比较,围绝经期组、绝经早期组及绝经晚期组血清TC、TG水平明显升高,差异有统计学意义(P<0.05),血清TG水平与KMI正相关(r=0.294,P=0.005),TC水平与KMI正相关(r=0.244,P=0.021)。结论:①女性绝经后血清E2、T水平明显降低,FSH水平显著升高。KMI与血清E2水平负相关,与血清FSH水平正相关。②妇女绝经后血清TG、TC水平显著升高,TG、TC与KMI正相关。

Correlation between serum sex hormones levels, blood lipids levels and perimenopausal symptoms

Objective:To research the correlation between serum sex hormones levels,blood lipids levels and perimenopausal symptoms.Methods:The general condition,perimenopausal quality of life,and Kupperman index(KMI) of 215 women were investigated,then 90 study objects were selected and divided into five groups: control group(20 women),perimenopausal group(17 women),early postmenopausal group(21 women),late postmenopausal group(22 women),and hormone replacement therapy(HRT) group(10 women);the serum levels of estradiol,follicle-stimulating hormone(FSH),testosterone(T),total cholesterol(TC),and triglyceride(TG) were detected and compared,respectively;the perimenopausal symptoms and KMI were compared,and the correlation was analyzed.Results:Compared with control group,the serum levels of estradiol and T in perimenopausal group,early postmenopausal group,and late postmenopausal group decreased significantly(P<0.05).KMIs in perimenopausal group,early postmenopausal group,and late postmenopausal group increased gradually,which were statistically significantly higher than that in control group(P<0.05).There was a negative correlation between estradiol level and KMI(γ=-0.334,P=0.001),there was a negative correlation between T level and KMI(γ=-0.270,P=0.010),there was a positive correlation between FSH level and KMI(γ=0.504,P=0.000);compared with control group,serum TC and TG levels in perimenopausal group,early postmenopausal group,and late postmenopausal group increased significantly(P<0.05),there was a positive correlation between serum TG and KM(γ=0.294,P=0.005),there was a positive correlation between TC and KMI(γ=0.244,P=0.021).Conclusion:Serum estradiol and T levels decrease obviously in postmenopausal women,but serum FSH level increases.There is a negative correlation between KMI and serum estradiol,but KMI is positively correlated with serum FSH.Serum TG and TC levels of postmenopausal women increase significantly,TG and TC levels are positively correlated with KMI.