胸腔积液腺苷脱氨酶检测诊断价值的研究

目的探讨胸水中腺苷脱氨酶(ADA)的检测在鉴别结核性、漏出性及恶性胸水方面的临床诊断价值。方法收集患者胸水标本共93例,分为癌性胸水组、结核性胸水组和漏出性胸水组,用酶偶联连续监测法分别测定其腺苷脱氨酶(ADA)水平。结果 3组胸水中腺苷脱氨酶测定值分别为(14.24±12.90)U/L、(49.36±15.75)U/L、(10.12±7.87)U/L,其中结核性胸水中的腺苷脱氨酶(ADA)与漏出液组比较差异有统计学意义(P0.01)。结论腺苷脱氨酶对结核性胸腔积液的鉴别诊断有较高价值,可作为一种诊断结核性胸腔积液的辅助手段。

Diagnostic Value of ADA for Pleural Effusion

Objective To observe the value of adenosine deaminase(ADA)in differential diagnosis of hydrothorax.Methods In this study,93 subjects were collected in the second Xiangya hospital from Oct 2007 to Mar 2008.The patients were divided into three groups.which were the malignant hydrothorax group,the tuberculous hydrothorax group and the transudative hydrothorax group.We measured the adenosine deaminase(ADA)in pleural effusion of every patients with continuous monitored enzymatic method.Results The values of ADA in the three group were(14.24±12.90)U/L,(49.36±15.75)U/L and(10.12±7.87)U/L,respectively.There were significant differences for the values of adenosine deaminase(ADA)among the three groups,For instance,The value of adenosine deaminase(ADA)in the tuberculous hydrothorax group was greatly different with that of the transudative hydrothorax group(P＜0.01).Conclusion Detection of adenosine deaminase(ADA)has highly differential diagnosis value and can be as supplementary method to diagnose tuberculous hydrothorax.