神经元特异性烯醇酶与急性脑梗死

目的：探讨急性脑梗死患者血清神经元特异性烯醇酶（NSE）的变化及其临床意义。方法：采集69例脑梗死患者起病3天内的血标本，用酶联免疫分析法测定血清NSE含量（其中35例2周时复测）。结果脑梗死3天内血清NSE明显高于对照组及2周时（P＜0．001），血清NSE含量与梗死灶大小，神经功能缺损程度明显正相关（P＜0．001），与意义障碍明显负相关（P＜0．001），临床疗效赵差血清NSE含量越高（P＜0．001）。结论：脑梗死早期血清NSE明显升高，血清NSE含量与临床表现关系密切。

Neuron-specific enolase and acute cerebral infarction

Objective To explore the change and clinical significance of serum neuron specific enolase (NSE) in the patients with acute cerebral infarction.Methods Blood samples(serum NSE levels) of 69 patients with cerebral infarction were determined by ELISA in the first 3 days,and 35 patients of them were determined again 2 weeks the onset.Results NSE serum levels of patients were significantly higher in the first 3 days than in 2 weeks after the onset and the controls( P <0.001),there was a positive correlation between serum NSE levels and the volume of infraction, neurological deficit scores( P <0.001),and it was negative correlation with disorder of consciousness( P <0.001),the higher serum NSE levels indicated the worse clinical curative effect( P <0.001).Conclusion Serum NSE levels were increased in the early stage of cerebral infarction, and there was a close relationship between NSE serum levels and clinical features.