The impact of transfusion of leucodepleted platelet concentrates on cytomegalovirus disease after allogeneic stem cell transplantation |
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Authors: | Ronghe Milind D Foot Annabel B M Cornish Jaqueline M Steward Colin G Carrington David Goulden Nicholas Marks David I Oakhill Anthony |
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Affiliation: | BMT Unit, Bristol Royal Hospital for Children, Bristol, UK. |
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Abstract: | The impact of transfusion of leucodepleted platelet concentrates (PCs) on cytomegalovirus (CMV) disease was assessed in 215 allogeneic (145 unrelated and 70 related donor) transplants over 3 years. In 43%, both donor and patient were CMV seronegative (CMV-/-). All received CMV-seronegative red cells and random leucodepleted PCs. No CMV disease occurred in any CMV-/- (low risk) transplant. CMV infection occurred in 31 seropositive patients (26%); 13 died and five deaths were attributable to CMV disease. When compared with historical controls, who received CMV-seronegative PCs, we found no difference in transfusion-acquired CMV in the current cohort. |
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Keywords: | stem cell transplantation cytomegalovirus disease transfusion leucodepletion platelet concentrates |
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