高原地区严重创伤后多脏器功能不全患者凝血功能的变化及意义

目的:分析高海拔地区严重创伤后多脏器功能不全患者凝血功能的变化,及其对病情严重度和预后的判断价值.方法:回顾分析了我院急救中心2006年7月-2011年6月收治的来自海拔2260m～4 000m的青海省内168例严重创伤患者(NISS≥20),按有无并发多脏器功能不全综合征(MODS)分为MODS组和非MODS组；分为...

Changes of Coagulation Function and its Significance in Patients with Multiple Organ Dysfunction Syndromes (MODS)after Serious Trauma at High Altitude

Objective:To investigate the relationship between coagulation dysfunction and severity and prognosis of patients after serious traumatic at high altitude.Methods:The documents of 168 patients with serious trauma(NISS≥20)from different geographic altitude(2 260m~4 000m) in Qinghai area were reviewed in our hospital from July 2006 to June 2011.They were divided into three groups: the multiple organ dysfunction syndrome(MODS) vs.non-MODS,and the survival vs.death,or the normal and abnormal group according to the blood coagulation index,such as platelets and the four coagulation indices measured,and NISS scores were determined at the admission day.Results:The level of platelet was lower,furthermore the level of D-Dimer,fibrin degradation product(FDP) were dramatically higher in MODS and death cases than those in non-MODS and survival patients respectively,as well prothrombin time(PT) and active partial thromboplastin time(APTT) were obviously prolonged in MODS patients.And APTT、PT were obvious prolonged in death cases.NISS scores were significantly higher in patients with abnormal coagulation indices as compared with patients with normal indices.Conclusions:The coagulation dysfunction of serious traumatic patients is associated with the severity and prognosis of the illness at high altitude.