Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial |
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Authors: | P SIEG H VON DOMARUS V VON ZITZEWITZ H IVEN L FÄRBER† |
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Institution: | Department of Head and Neck Surgery, Medical University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany;Department of Pharmacology, Medical University of Lübeck, Germany;Sandoz AG, Clinical Research, Nürnberg, Germany |
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Abstract: | The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement in disease activity. Contradictory results from earlier reports are discussed. |
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