E-钙黏蛋白及基质金属蛋白酶-9与肺癌侵袭转移的相关性研究

目的:研究上皮性钙黏素(E-cadherin)、基质金属蛋白酶-9(MMP-9)在非小细胞肺癌(nonsmall cell lung cancer,NSCLC)组织中的表达,探讨其与NSCLC侵袭和转移的关系。方法:采用免疫组织化学SP方法检测E-cadherin和MMP-9在78例肺癌标本中的表达。结果:E-cadherin在肺癌中的阳性表达率为58.97%,其表达率与分化程度有相关性(P<0.05),在有淋巴结转移病例中E-cadherin表达率明显低于无淋巴结转移病例(P<0.01);MMP-9在肺癌中的阳性表达率为71.79%,其表达率与淋巴结转移呈正相关。E-cadherin高表达者生存时间长,MMP-9高表达者生存时间短。结论:肺癌组织中E-cadherin和MMP-9的表达与肺癌淋巴结转移有显著相关性,检测这2种蛋白表达将有助于判断肺癌的转移及预后。

Relationship Between E - cadherin、 MMP- 9 and Invasion and Metatasis in Lung Cancer

Objective:To determine the expression of E-cadherin,matrix metalloproteinase-9(MMP-9) in non small cell lung cancer(NSCLC)and investigate their association with the invasion and metastasis of NSCLC.Methods: The expression of E-cadherin and MMP-9 were detected in 78 cases of lung cancer by immunohistochemistry SP methods.Results: The positive rates of E-cadherin was 58.97%,there was a statistically significant difference between well differentiated cells and moderatly and poorly differentiated cells(P<0.05),the expression of E-cadherin in lung cancer tissues with lymph node metastasis was significantly lower than those without lymph node metastasis(P<0.05),The positive rates of MMP-9 was 71.79%,the expression of MMP-9 had a positive correlation with lymph node metastasis(P<0.05).The patients who had high expression of E-cadherin had a longer survival time,while the patients who had high expression of MMP-9 had a shorter survival time.Conclusion:Expression of E-cadherin and MMP-9 are closely associated with lymph node metastasis of lung cancer,which are indicators of metastasis and prognosis in lung cancer.