白大衣高血压患者的血小板功能

目的:探讨白大衣高血压(WCH)患者的血小板功能.方法:选初诊的原发性高血压(EH)患者、 WCH 患者、正常血压(NT)者各35例,通过诊室血压测量和24 h动态血压监测,同时测定并比较3组血小板最大聚集率(PAGTmax)、血浆血小板α-颗粒膜蛋白(GMP-140)含量、平均血小板容积(MPV) 、血小板数量的变化.结果:和NT对照组相比,EH组和WCH组 PAGTmax、血浆血小板GMP-140含量、MPV均明显增加(P<0.05)而三组血小板计数无统计学差异,同时EH组的PAGTmax、血浆血小板GMP-140含量、MPV均高于WCH组(P<0.05).EH组和WCH组MPV与24 h平均舒张压、GMP-140含量均正相关( P<0.05).结论:WCH存在血小板活化,可能和心血管事件发生率增加有关.

Analysis of platelet function in patients with white coat hypertension

Objective:To investigate the change of platelet function in patients with essential hypertension (EH), white coat hypertension (WCH)and normotension (NT). Method:Participants were classified as EH (n= 40), WCH (n= 40), or NT (n= 40) on the basis of clinic and 24 hour ambulatory blood pressure monitoring. The change of maximum platelet aggregation rate(PAGTmax),the level of platelet alpha-granule membrane protein(GMP-140)and the mean platelet volume (MPV)were measured between the subjects.Result:Compared with NT controls, the PAGTmax, the level of GMP-140 and the MPV were significantly higher in patients with EH and WCH (P<0.05), those were also higher in essential hypertensives than in white coat hypertensives(P<0.05). MPV was positively correlated with the level of GMP-140 and the 24 hour ambulatory diastolic blood pressure in EH group as well as in WCH group.Conclusion:There exist enhanced platelet activity in WCH by which white coat hypertensive may be at increased cardiovascular risk.