Prior Fundoplication Does not Improve Safety or Efficacy Outcomes of Radiofrequency Ablation: Results from the U.S. RFA Registry |
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Authors: | Nicholas J Shaheen Hannah P Kim William J Bulsiewicz William D Lyday George Triadafilopoulos Herbert C Wolfsen Srinadh Komanduri Gary W Chmielewski Atilla Ertan F Scott Corbett Daniel S Camara Richard I Rothstein Bergein F Overholt |
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Institution: | 1. University of North Carolina School of Medicine, 130 Mason Farm Rd, CB#7080, Chapel Hill, NC, 27599-7080, USA 2. Atlanta Gastroenterology Associates, Atlanta, GA, USA 3. Stanford University School of Medicine, Palo Alto, CA, USA 4. Mayo Clinic Florida, Jacksonville, FL, USA 5. Northwestern University School of Medicine, Chicago, IL, USA 6. William Beaumont Hospital, Detroit, MI, USA 7. University of Texas Medical School, Houston, TX, USA 8. Gastroenterology Associates of Sarasota, Sarasota, FL, USA 9. Digestive Health Physicians, Cheektowaga, NY, USA 10. Dartmouth University School of Medicine, Hanover, NH, USA 11. Gastrointestinal Associates, Knoxville, TN, USA
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Abstract: | Background Ongoing gastroesophageal reflux may impair healing and re-epithelialization after radiofrequency ablation (RFA) of Barrett’s esophagus (BE). Because prior fundoplication may improve reflux control, our aim was to assess the relationship between prior fundoplication and the safety/efficacy of RFA. Methods We assessed the U.S. RFA Registry, a nationwide registry of BE patients receiving RFA at 148 institutions, to compare the safety and efficacy of ablation between those with prior fundoplication and those with medical management (proton pump inhibition). Results Among 5,537 patients receiving RFA, 301 (5.4 %) had prior fundoplication. Of fundoplication subjects, 1.0 % developed stricture and 1.0 % were hospitalized after RFA. Rates of stricture, bleeding, and hospitalization were not statistically different (p?=?ns) between patients with and without prior fundoplication. Complete eradication of intestinal metaplasia and complete eradication of dysplasia were achieved in 71 % and 87 % of fundoplication patients, and 73 % and 87 % of patients without fundoplication, respectively (p?=?ns for both). Patients with prior fundoplication needed similar numbers of RFA sessions for eradication compared with those without fundoplication. Conclusions Radiofrequency ablation, with or without prior fundoplication, is safe and effective in eradicating BE. Prior fundoplication was associated with similar adverse event and efficacy rates when compared with medical management. |
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