Regulation of β-cell mass and function by the Akt/protein kinase B signalling pathway |
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Authors: | L. Elghazi,L. Rachdi,A. J. Weiss,C. Cras-Mé neur,E. Bernal-Mizrachi |
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Affiliation: | Department of Internal Medicine, Division of Endocrinology, Washington University School of Medicine, Metabolism &Lipid Research, St Louis, MO 63110, USA |
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Abstract: | The insulin receptor substrate-2/phosphoinositide 3-kinase (PI3K) pathway plays a critical role in the regulation of β-cell mass and function, demonstrated both in vitro and in vivo . The serine threonine kinase Akt is one of the promising downstream molecules of this pathway that has been identified as a potential target to regulate function and induce proliferation and survival of β cells. Here we summarize some of the molecular mechanisms, downstream signalling pathways and critical components involved in the regulation of β-cell mass and function by Akt. |
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Keywords: | apoptosis Akt β-cell mass β-cell proliferation diabetes GSK3 IRS1 IRS2 mTOR pancreatic islets PI3K PKB |
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