Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection - a new frontier? |
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Authors: | Arash Afshari Jacques Schrenzel Margareta Ieven Stephan Harbarth |
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Institution: | Infection Control Program, Geneva University Hospitals and Medical School, 4, rue Gabrielle-Perret-Gentil, CH-1211 Geneva 14, Switzerland. stephan.harbarth@hcuge.ch. |
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Abstract: | ABSTRACT: Among critically ill patients, the diagnosis of bloodstream infection poses a major challenge. Current standard bacterial identification based on blood culture platforms is intrinsically time-consuming and slow. The continuous evolvement of molecular techniques has the potential of providing a faster, more sensitive and direct identification of causative pathogens without prior need for cultivation. This may ultimately impact clinical decision-making and antimicrobial treatment. This review summarises the currently available technologies, their strengths and limitations and the obstacles that have to be overcome in order to develop a satisfactory bedside point-of-care diagnostic tool for detection of bloodstream infection. |
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