| 妊高征患者蜕膜组织中淋巴细胞转化率及细胞因子活性的变化 |
| |
| 引用本文： | 郝淑维,崔澂,黄丽珍.妊高征患者蜕膜组织中淋巴细胞转化率及细胞因子活性的变化[J].生殖与避孕,2004,24(2):82-85. |
| |
| 作者姓名： | 郝淑维 崔澂 黄丽珍 |
| |
| 作者单位： | 1. 河北医科大学第四医院妇产科,石家庄,050011
2. 中国人民解放军白求恩军医学院,石家庄,050081 |
| |
| 摘 要： | 目的:研究妊娠高血压综合征(简称妊高征)的免疫学发病机制。方法:通过测定妊高征患者及正常孕妇蜕膜组织中淋巴细胞转化率,检测细胞培养液上清中白细胞介素-1(IL-1)、白细胞介素-2(IL-2)及肿瘤坏死因子α的活性,探讨妊高征的免疫学发病机制。结果:实验组淋巴细胞转化率、IL-1、IL-2、TNF-α活性均比对照组高,有显著统计学意义。且IL-2活性升高与淋巴细胞转化率存在明显的直线正相关。结论:蜕膜组织中的细胞因子异常升高及T细胞可能处于高免疫激活状态参与了妊高征的免疫学发病机制。
|
| 关 键 词： | 妊娠高血压综合征(妊高征) 细胞因子 淋巴细胞转化率 蜕膜 |
| 文章编号： | 0253-357X(2004)02-0082-04 |
| 修稿时间： | 2003年5月8日 |
Change of Decidual Tissue Lymphocyte Transforming Ratio and Activity of Cytokines |
| |
| Shu-wei HAO,Cheng CUI,Li-zhen HUANG.Change of Decidual Tissue Lymphocyte Transforming Ratio and Activity of Cytokines[J].Reproduction and Contraception,2004,24(2):82-85. |
| |
| Authors: | Shu-wei HAO Cheng CUI Li-zhen HUANG |
| |
| Institution: | Shu-wei HAO,Cheng CUI,Li-zhen HUANG
Department of Obsterics and Gynecology,No.4 Hospital,Hebei Medical University,Shijiazhuang,050011 Microbiology and Immunology,PLA Bethune Medical College,Shijiazhuang,050081 |
| |
| Abstract: | Objective: To study the immunological mechanism in pregnancy induced hypertension syndrome (PIH syndrome).Methods: Ratio of lymphocyte transforming and production of interleukin-1, interleukin-2, tumor necrosis factor-alpha were measured in PIH patient and normal pregnant women. Results: In decidual tissue of patients with PIH syndrome, the ratio of lymphocyte transforming and the production of interleukin-1, interleukin-2, turner necrosis factor-alpha rised. Conclusion: Secretions of interleukin-1, interleukin-2, turner necrosis factor alpha of monocytes/macrophages and T lymphocytes are higher significantly, proportion of lymphocyte transforming increases, which could possibly be involved in the immunological mechanism of PIH syndrome. |
| |
| Keywords: | pregnancy induced hypertension syndrome (PIH syndrome) cytokines ratio of lymphocyte transforming decidua |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
