| 助孕胶囊对PCO模型大鼠血清INH-ACT-FS系统的影响 |
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| 引用本文： | 刘润侠,陈梅,党慧敏,尚利.助孕胶囊对PCO模型大鼠血清INH-ACT-FS系统的影响[J].中医药导报,2008,14(10). |
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| 作者姓名： | 刘润侠 陈梅 党慧敏 尚利 |
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| 作者单位： | 西安交通大学医学院第二附属医院,陕西,西安,710004 |
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| 摘 要： | 目的:观察助孕胶囊对PCO模型大鼠血清性激素水平及INH-ACT-FS系统的影响,探讨其对PCOS的治疗作用并分析其可能的作用机制.方法:采用胰岛素联合HCG造模法制备PCO模型大鼠.随机分为对照组、模型组、助孕胶囊组、二甲双胍组.运用放射免疫法测定血清性激素、胰岛素(INS)水平;双抗体夹心酶联免疫吸附法测定血清抑制素(INHB)、激活素(ACTA)及卵泡抑素(FS)的水平.结果:助孕胶囊可明显下调PCO大鼠血清睾酮(T)、促黄体生成素(LH)、INS水平;并能上调血清ACT水平,降低血清INH、FS水平;且INS与ACTA呈负相关,与INHB呈正相关.结论:INH-ACT-FS系统在多囊卵巢的发生、发展中起重要作用;高胰岛素血症与INH-ACT-FS系统有关;助孕胶囊能够通过调整H-P-O轴及影响卵巢局部细胞因子INH、ACT、FS的表达,从而调节生殖内分泌,促进卵泡的发育、成熟及排卵.
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| 关 键 词： | 多囊卵巢综合征 助孕胶囊 INH-ACT-FS系统 性激素 胰岛素 |
The Effects of Zhuyun JiaoNang on the Inhibin-Activin-Follistatin System in Model Rats with Polycystic Ovary |
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| LIU Run-xia,CHEN Mei,DANG Hui-min,SHANG Li.The Effects of Zhuyun JiaoNang on the Inhibin-Activin-Follistatin System in Model Rats with Polycystic Ovary[J].GUIDING JOURNAL OF TCM,2008,14(10). |
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| Authors: | LIU Run-xia CHEN Mei DANG Hui-min SHANG Li |
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| Institution: | LIU Run-xia,CHEN Mei,DANG Hui-min,SHANG Li The Second Affiliated Hospital,Medical College of Xi\'an Jiaotong University,Xi\'an,China,710004 |
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| Abstract: | Objective: To observe the effects of ZhuYun JiaoNang(ZYJN) on procreate endocrine hormone and inhibin-activin-follistatin system in rat of polycystic ovary(PCO),analyzing the possible therapeutic mechanism and therapeutical effect.Methods: The PCO rat models were set by insulin combining with human chorionic gonadotrophin(HCG),randomLy divided into four group,which included control group,model group,Chinese crude drug group(ZYJN) and western medicine group(DMBG).The levels of serum gonadal hormone and insul... |
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| Keywords: | Polycystic ovarian syndrome Zhuyun Jiaonang Inhibin-activin-follistatin system Gonadal hormonal Insulin |
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