子宫内膜异位症在位和异位内膜组织蛋白酶D的研究

目的探讨组织蛋白酶D在子宫内膜异位症（内异症）在位和异位内膜中的表达及意义。方法应用免疫组织化学及图像分析方法比较组织蛋白酶D在正常子宫内膜、内异症在位及异位内膜中的含量。结果正常子宫内膜和内异症在位内膜腺上皮的组织蛋白酶D随月经周期呈现周期性变化，分泌期显著高于增生期；内异症在位内膜腺上皮组织蛋白酶D的表达与正常子宫内膜无明显差异；卵巢子宫内膜异位囊肿中异位内膜腺上皮组织蛋白酶D的表达显著高于同组患者的在位内膜。结论内异症异位内膜腺上皮组织蛋白酶D的表达增高与内异症的发病密切相关。

Study of cathepsin D in eutopic and ectopic endometria from patients with Endometriosis

Objective To study the role of cathepsin D in the pathogenesis of endometriosis. Methods Cathepsin D in normal cndometria, eutopic and eetopic endometrla from patients with ovarian endometriosis were examined by means of immunohistochemistry and image analysis. Results The immunostaining intensity of cathepsin D in eutopie endometrial epithelial cells of normal cycling women and patients with endometriosis was cycle-dependent. The content of cathepsin D was considerablely higher in the secretory phase compared with that in the proliferative phase. The intensity of cathepsin D expression in eutopie endometrial epithelial cells of endometriosis showed no difference, when compared with that of normal endometrium in the same phase. The eetopic endometrial epithelial cells showed a higher intensity of eathepsin D expression than eutopic endo- metrium of endometriotie patients did. Conclusion The abnormal expression of cathepsin D in ectopic endome- tria might play a significant role in the pathogenesis of endometriosis.