肝动脉栓塞微球的研究

本文用乳化聚合法制备了明胶和聚乙烯醇两种微球,通过正交试验,确定了制备特定粒径微球的最佳工艺条件。以氟脲嘧啶和甲氨喋呤为模型药物,对明胶微球的体外溶出特性进行了探讨,结果表明,经复合交联能延缓药物的体外溶出。实验狗灌注微球前后的肝动脉造影表明术后肝动脉分枝有不同程度的减少;病理检查表明微球沉积于肝血窦前的肌性小动脉;γ-射线扫描也证实锝标记微球在肝内的特异性分布。

STUDY ON MICROSPHERES FOR EMBOLIZATION OF HEPATIC ARTERY

In this paper microspheres for embolization of hepatic artery have been prepared from gelatin and polyvinyl alcohol by emulsion polymerization, and systematic studies on the pharmaceutical aspects of microspheres, including the manuiacturing procedures, microsphere size and size distribution, drug incorporation, determination of the drug in the microspheres, their dissolution in vitro and the stability during sterilization by gamma radiation were conducted, By orthogonal designs on several factors affecting size and size distribution, optimal procedures in preparing microspheres with special size have been established. Using methotrexate and 5-fluorouracil as the model drugs, the release characteristics of gelatin microspheres were investigated. By complex chemical cross-linking the release of drug from microspheres could be delayed.The pathologic examination showed that microspheres infused via a percutaneously introduced catheter into the hepatic artery could occlude muscular arterioles before hepatic blood sinuses. Angiography which was performed before and immediately after each embolization illustrated that the branches of hepatic artery disappeared to a variable extent. γ-Ray scanning also illustrated the special localization of ^99mTc labelling microspheres in liver.