细胞因子在幽门螺杆菌相关胃炎中的分泌及临床意义

目的探讨幽门螺杆菌(HP)相关胃炎血清肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)及超敏C反应蛋白(hs-CRP)水平及临床意义。方法选择110例慢性浅表性胃炎患者为研究对象,其中HP阳性者58例,HP阴性者52例。比较两组患者TNF-α、IL-8及hs-CRP水平及根除HP治疗前后炎症因子的改变。结果 HP阳性者TNF-α、IL-8及hs-CRP水平显著高于HP阴性者(P<0.01);HP阳性组活动期胃炎患者TNF-α、IL-8及hs-CRP水平显著高于非活动期患者(P<0.01);根除HP治疗后TNF-α、IL-8及hs-CRP水平显著下降(P<0.01)。结论细胞因子TNF-α、IL-8及hs-CRP水平的升高与胃黏膜HP感染密切相关,可作为活动期胃炎及治疗效果的判断指标之一。

Secretion of cytokines in Helicobacter pylori-associated gastritis and clinical significance

Objective To explore the secretion of TNF-α,IL-8 and hs-CRP in Helicobacter pylori-associated gastritis and clinical significance.Methods One hundred and ten patients with chronic superficial gastritis were divided into HP-positive group（n=58） and HP-negative group（n=52）.Serum TNF-α,IL-8 and hs-CRP levels between two groups and their pre-and post-treatment levels in HP-positive group were compared.Results The levels of TNF-α,IL-8 and hs-CRP in HP-positive group were higher than those in HP-negative group（P0.01）.TNF-α,IL-8 and hs-CRP levels in active gastritis were higher than the patients without active gastritis（P0.01） in HP-positive group.Serum TNF-α,IL-8 and hs-CRP levels were decreased after treatment in HP-positive group（P0.01）.Conclusion Enhanced levels of TNF-α,IL-8 and hs-CRP have a close relationship with HP infection of gastric mucosa,and can be prognostic indexes for active gastritis and treatment effect.