双能量CT技术在肺孤立性结节中的诊断价值

目的探讨双能量CT技术检测肺孤立性结节(SPN)内钙质含量,评价SPN良、恶性的价值。方法用多层CT双能量(140 kV、80 kV)对氯化钙模体、SPN行靶区轴向扫描,图像数据使用CT Perfusion 3软件处理,分析18例SPN患者CT值变化与钙盐含量关系,评价SPN钙盐含量,判断其良、恶性。结果氯化钙模体浓度与低能量(80 kV)比高能量(140 kV)时CT值的增加值呈正相关(P<0.001);SPN中以低能量比高能量时的CT值增加判断其良、恶性的敏感率为82%,特异性为86%,P<0.005。结论双能量CT技术判断SPN的良、恶性有很高的临床价值。

Study on clinical significance of dual-energy computed tomography in diagnosis of solitary pulmonary nodule

Objective To evaluate of the significance of using dual - energy CT to detect calcium content in solitary pulmonary nodules （SPN） and to distinguish benign from malignant nodules. Methods Dual - energy CT （ 140 kV, 80 kV） was performed for detection of calcium chloride contained phantom in patients with SPN, the CT Perfusion 3 software was used for imaging data processing to analyze the relationship between changes of CT value and calcium contents, and to study the calcium content of SPN in order to distinguish benign from malignant nodules. Results The concentration of calcium chloride in phantom was positively correlated with the increase in CT value with low energy （80 kV） than high energy （ 140 kV） （ P 〈0. 001 ）. The SPN containing calcium was also demonstrated for increased CT value in low energy scanning （ sensitivity 82% and specificity 86%, P 〈 0. 005 ）. Conclusion The method applied to differentiate benign and malignant SPN with high clinical significance is worthy to be clinically applied.