Low Postprandial Circulating Inactive Ghrelin: Role of Early Satiety in Undernourished Children |
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Authors: | Khadijehsadat Najib Mozhgan Moghtaderi Shirin Farjadian Ebrahim Falahzadeh |
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Affiliation: | 1. Allergy Research Center, Shiraz University of Medical Sciences, Zand St, 71348-45794, Shiraz, Iran 2. Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran 3. Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran 4. Department of Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran
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Abstract: | Objective To determine difference in the levels of circulating inactive ghrelin between undernourished and healthy children. Methods The present cross-sectional study was conducted in undernourished children from southwestern Iran, from July 2011 through July 2012. Postprandial inactive ghrelin levels were measured in 40 undernourished children and sex- and age-matched healthy controls by enzyme immunoassay. Results The levels of postprandial inactive ghrelin were considerably lower in undernourished compared to the healthy children (6.4 vs. 12.9, P?0.001). Among the undernourished children, the level of inactive ghrelin was significantly lower in girls than in boys (5.8 vs. 7.1, P?=?0.032). Conclusions Thus, the levels of inactive ghrelin was found to be low in undernourished children compared to healthy children. Early loss of appetite might be a result of low circulating inactive ghrelin levels in the postprandial state in undernourished children. |
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