Mixed Lymphocyte Culture Search for HLA-D Homozygous Typing Cells in the Hungarian Inbred Population of Ivád |
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| Authors: | Clara Ó nody,Tom Kristensen,J. Nemeské ry,Eva Gyó dy,Gabriella Bá tory,Katherine Bojá rszky |
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| Affiliation: | National Institute of Hematology and Blood Transfusion, Budapest, Hungary;Tissue Typing Laboratory, University Hospital, Aarhus, Denmark;Demographic Research Institute, Budapest, Hungary;Semmelweis Medical University Research Group for Gerontology, Budapest, Hungary |
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| Abstract: | Six functionally HLA-D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivád. These putative HLA-D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility reference reagents. The different HLA-D specificities could thus be identified: one closely matching HLA-Dw5, another resembling the Oslo LDoH specificity, while the last seems to be unique. Only one of the typing cells thus ascertained were HLA-B homozygous and were selected on the basis of the Ivád family structure and not on the basis of serological HLA typing. |
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