恩丹西酮和地塞米松预防小儿术后恶心呕吐的临床研究

目的:研究恩丹西酮和地塞米松预防小儿术后恶心呕吐(PONV)的临床效果。方法:选择120例手术患儿分4组,每组30例。Ⅰ组:静注生理盐水;Ⅱ组:地塞米松0.1mg/kg;Ⅲ组:恩丹西酮0.1mg/kg;Ⅳ组:地塞米松0.1mg/kg加恩丹西酮0.1mg/kg。比较各组患儿PONV的发生率。结果Ⅱ、Ⅲ、Ⅳ组PONV发生率明显低于Ⅰ组(P<0.005),Ⅳ组也明显低于Ⅱ、Ⅲ组(P<0.005),Ⅱ、Ⅲ组间无明显差异(P0.005)。结论:恩丹西酮和地塞米松均可有效预防小儿PONV,两药联合应用效果更佳。

The prophylactic against postoperatively nausea and vomiting of ondan -setron combined with Dexamethasone in children

Objective:To explore the prophylactic effect against PONV(postoperatively nausea and vomiting)of Ondansetron combined with Dexamethasone in children.Methods:120 children patients were selected and divided into 4 groups randomly (n=30). All the patients were given saling 2 ml intravenously in Group Ⅰ,Dexamethasone 0.1 mg/kg in GroupⅡ,Ondansetron 0.1 mg/kg in Group Ⅲ and Dexamethasone+Ondansetron (0.1 mg/kg) in GroupⅣ. The rate of PONV in each group was recorded and analyzed statistically. Results:The rate of PONV in Group Ⅱ,Ⅲ and Ⅳ was significantly lower than that in Group Ⅰ(P<0.005) and it was lower in Group Ⅳ than that in Group Ⅱ or in Group Ⅲ(P<0.005),however,there was no significant difference between Group Ⅱ and Group Ⅲ(P0.005).Conclusion:Ondansetron or Dexamethasone can prevent PONV in children and combined use of two drugs is more effective.