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| 胰高血糖素瘤综合征1例 | |
| 引用本文： | 曾建英,王宝玺,马东来,郑艳红,张少华,张葵. 胰高血糖素瘤综合征1例[J]. 临床皮肤科杂志, 2002, 31(11): 702-704 |
| 作者姓名： | 曾建英 王宝玺 马东来 郑艳红 张少华 张葵 |
| 作者单位： | 1. 中国医学科学院中国协和医科大学北京协和医院皮肤科,北京,100730 2. 首钢总医院皮肤科,北京,100041 3. 中国医学科学院中国协和医科大学北京协和医院核医学科,北京,100730 4. 中国医学科学院中国协和医科大学北京协和医院内分泌科,北京,100730 |
| 摘 要： | 报道1例46岁男性病人，全岙皮肤红斑、水疱3年，加重1年，具有典型的坏死松解性游走性红斑，伴舌炎、糖尿病，体重下降，血胰高血糖素增高。皮肤组织病理变化为表皮浅层坏死，免疫组化发现表皮浅层抗人胰高血糖素抗体着色阳性。腹部CT及锝标记生长抑素类似物（Octreotide）扫描显示患者胰尾及肝脏肿瘤。长效生长抑素治疗后，血胰高血糖素水平在短期内明显下降，皮诊逐渐好转。 |
| 关 键 词： | 胰高血糖素瘤综合征 坏死松解性游走性红斑 生长抑素 内分泌肿瘤 CT 诊断 治疗 |
| 文章编号： | 1000-4963(2002)11-0702-03 |
| 修稿时间： | 2001-12-07 |
Glucagonoma syndrome: a case report |
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| ZENG Jian-ying,WANG Bao-xi,MA Dong-lai,ZHENG Yan-hong,ZHANG Shao-hua,ZHANG Kui. Glucagonoma syndrome: a case report[J]. Journal of Clinical Dermatology, 2002, 31(11): 702-704 | |
| Authors: | ZENG Jian-ying WANG Bao-xi MA Dong-lai ZHENG Yan-hong ZHANG Shao-hua ZHANG Kui |
| Abstract: | A46-year-old male presented with erythemas and blisters for three years that exacerbated for one year was re-ported.He had clinically characteristic necrolytic migratory erythema(NME),glossitis,diabetes mellitus,weight loss and hy-perglucagonemia.Skin biopsies showed necrosis of the superficial epidermis and immunohistochemical studies revealed glucagon deposition in the same areas.Computerized topography scanning and Octreotide radiography revealed multiple tu-mors in his pancreas tail and liver.After treatment with somatostatin analog,Lanreotide,the level of blood glucagon de-creased and the skin rash re covered gradually. |
| Keywords: | glucagonoma syndrome necrolytic migratory erythema lanreotide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |