益胰降糖合剂治疗2型糖尿病胰岛素抵抗患者40例临床观察

目的：研究益胰降糖合剂治疗2型糖尿病胰岛素抵抗的临床疗效及其作用机理。方法：将80例2型糖尿病胰岛素抵抗患者按照分层随机的方法，以1：1的比例分别进入西药（二甲双胍）组、治疗（益胰降糖合剂）组。疗程均为1个月，观察临床疗效及治疗前后空腹血糖（FPG）、空腹胰岛素（FIN）、餐后2h血糖（P2hPG）、糖基化血红蛋白（HbAIc）、血脂、胰岛素敏感指数（ISI）、胰岛素抵抗指数（IR）的变化。结果：治疗组有效率92．5％，明显优于西药组，有显著性意义（P〈0．05或P〈0．01），并且无不良反应。结论：益胰降糖合剂治疗2型糖尿病疗效显著，且能明显改善患者的胰岛素抵抗。

Clinical Observation of Yiyi Jiangtang Mixture for 40 Insulin-resistant Cases

Objective： To explore clinical efficacy and the mechanism of Yiyi Jiangtang Mixture for type Ⅱ diabetic patients with insulin- resistance. Methods：According to whether there is a complication, eighty patients were stratified and randomized to take Mefformin （40 cases ） , or Yiyi Jiangtang Mixture （40 cases） respectively for 1 month. Clinical efficacy and therapeutic indices of each medication were observed before and after treatment, including FPG, fasting insulin （FIN）, postprandial plasma glucose （2h, P2hPG）, glycosylated hemoglobin （HbAIc） , TC, TG, insulin sensitivity index （ISI）, insulin resistance （IR）. Results：The trial demonstrated Yiyi Jiangtang Mixture had a significantly higher effective rate of 92.5% than that of Metformin, and few noticeable adverse effects. Conclusion：Yiyi Jiangtang Mixture had significant therapeutic effectiveness for type Ⅱ diabetes and insulin resistance.