阿立哌唑与奎硫平治疗精神分裂症疗效研究

目的比较阿立哌唑与奎硫平治疗精神分裂症患者的疗效与不良反应。方法将142例首发精神分裂症患者,随机分为阿立哌唑组及奎硫平组进行治疗,分别在治疗前及治疗2、4、8周末采用阳性与阴性症状量表（PANSS）评定临床疗效,用治疗中出现的症状量表（TESS）评定药物不良反应。结果阿立哌唑的疗效与奎硫平相当,阿立哌唑的显效率81．69％奎硫平的显效率78．87％,组间比较差异无显著性（P〉0．05）。阿立哌唑组的不良反应明显少于奎硫平组,组间比较有显著性差异（P〈0．05）。结论阿立哌唑是一安全有效、不良反应少的抗精神分裂症药。

Comparative study of aripiprazole and quetiapine on treatment of schizophrenia

Objective To compare efficacy and safety of aripiprazole and quetiapine on the treatment of schizophrenia. Methods 142 patients with first episode schizophrenia were randomly divided into aripiprazole groupor quetiapine group. Positive and negative symptom scale (PANSS) and treatment emergent symptom cale (TESS) were used to evaluate the efficacy and adverse events of drugs before and after 2,4,8 weeks of treatments. Results The therapeutic efficacy in aripiprazole group was similar to that in quetiapine, the curative effectiveness of aripiprazole was 81.69%, and the curative effectiveness of quetiapine was 78.87%, there was no significant different between the two groups(P ＞ 0. 05 ). The side effects of aripiprazole is less than that of quetiapine, there was significant different between the two groups (P ＜ 0. 05 ). Conclusion Aripiprazole is one of effective and safe drugs in the treatment of schizophrenia.