胃癌病人血清IL—2R、IL—10、IL—12水平的变化

目的 观察胃癌病人血清可溶性白介素2受体（sIL-2R)、白介素10（IL－10)、白介素12（IL－12）表达水平的变化；方法 A组（正常对照组）12例，B组（胃癌带瘤组）22例，C组（胃癌术后半年内无复发组）20例，D组（胃癌术后半年以上无复发组）21例，ELISA法检测各组血清IL－2R、IL－10、IL-12水平。结果 与A组相比，B组的IL－2R水平明显升高（P＜0．005），B、C组的IL－12组的IL－12水平明显降低（P＜0．005）。与B组相比，D组的IL－2R水平明显降低（P＜0．005），IL－12水平明显回升（P＜0．05）。IL－12水平与IL－2R、IL－10水平无明显相关性。结论 胃癌病人血清IL－2R水平长高；IL－12水平降低，根除肿瘤后IL－2R、IL－12逐渐恢复正常。

Changes of Serum Soluble Interleukin 2 Receptor,Interleukin 10 and Interleukin 12 in Patients with Gastric Cancer

To observe the changes of serum interleukin 2 receptor (IL_2R),interleukin_10 (IL_10) and interleukin_12 (IL 12)in patients with gastric cancer.Patients were divided into four groups:group A(normal control,12 cases),group B(patients with gastric cancer burden,22 cases),group C(patients without recurrence within half a year after resection of gastric cancer,20 cases),group D(patients without recurrence beyond half a year after resection of gastric cancer,21 cases).Serum level of IL 2R,IL 10 and IL 12 were assayed by ELISA.Compared with group A,serum IL 2R in group B increased significantly (P<0.005),and IL 12 in group B and group C decreased significantly (P<0.005).Compared with group B,IL 2R in group D increased significantly (P<0.005),and IL 12 increased significantly(P<0.05).No obvious correlation between the level of IL 12 and IL 2R or IL 10 was found.Conclusion]In patients with gastric cancer,serum IL 2R increased and IL 12 decreased.After tumor eradicated curative IL 2R and IL 12 will return to normal level gradually.